Article
Increased frequencies of cytochrome P4501A1 polymorphisms in infertile men.
Andrologia - 1 Jan 2000
Fritsche E, Schuppe H C, Döhr O, Ruzicka T, Gleichmann E, Abel J
Abstract excerpt
Genetic factors that could mediate the pathogenesis of male reproductive disorders are largely unclear. Polymorphisms of cytochrome P4501A1 (CYP1A1), a key enzyme in the extrahepatic metabolism of lipophilic xenobiotics, have been shown to influence susceptibility to xenobiotics. Here, CYP1A1 polymorphisms were investigated in 134 infertile Caucasian men. The frequencies of the Mspl polymorphism in the...
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