Article
Smoking status modifies the relation between CYP1A1*2C gene polymorphism and idiopathic male infertility: the importance of gene-environment interaction analysis for genetic studies of the disease.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Nov 2013
Yarosh Sergey L, Kokhtenko Elena V, Starodubova Nina I, Churnosov Mikhail I, Polonikov Alexey V
Abstract excerpt
The study was designed to investigate the associations of polymorphisms Ile462Val and 3801T>C of the cytochrome P450 1A1 (CYP1A1) gene with idiopathic male infertility (IMI) and to assess the impact of smoking status on the relationship between the polymorphisms and the susceptibility to the disease. DNA samples from 203 patients with IMI and 227 fertile men were genotyped for the polymorphisms by a polymerase...
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