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Article

The spatial distribution of exposed nuclear DNA in normal, cancer, and reverse-transformed cells.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990

Krystosek A, Puck T T

Abstract excerpt

The malignant CHO-K1 cell is reverse-transformed by cAMP, regaining the phenotype of a normal fibroblast. During this reaction, much of its DNA re-acquires sensitivity to hydrolysis by DNase I in a way characteristic of the normal fibroblast. Exposed DNA forms a rim about the nucleus in both the normal and reverse-transformed cell but not in the malignant CHO-K1. Reacquisition of the nuclear rim requires an...

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Identifiers

PMID: 1697684
DOI: 10.1073/pnas.87.17.6560
PMCID: PMC54576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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