Article
The spatial distribution of exposed nuclear DNA in normal, cancer, and reverse-transformed cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990
Krystosek A, Puck T T
Abstract excerpt
The malignant CHO-K1 cell is reverse-transformed by cAMP, regaining the phenotype of a normal fibroblast. During this reaction, much of its DNA re-acquires sensitivity to hydrolysis by DNase I in a way characteristic of the normal fibroblast. Exposed DNA forms a rim about the nucleus in both the...
Topics
- 1-Methyl-3-isobutylxanthine
- 8-Bromo Cyclic Adenosine Monophosphate
- Animals
- Cell Line
- Cell Nucleus
- Cell Transformation, Neoplastic
- Chromatin
- Colforsin
- Cyclic AMP
- DNA
- DNA, Neoplasm
- Phenotype