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Article

HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology

19 Jun 1998

Abstract excerpt

Human immunodeficiency virus type-1 (HIV-1) manipulates fundamental host cell processes in sophisticated ways to achieve optimum replicative efficiency. Recent studies have provided new details on the molecular interactions of HIV-1 with its host cell. For example, HIV-1 encodes a protein that regulates transcriptional elongation by interacting with a cellular cyclin-dependent kinase, another that activates the...

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PMID: 9632380
DOI: 10.1126/science.280.5371.1880

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