Article
Yield of mtDNA mutation analysis in 2,000 patients.
American journal of medical genetics - 5 Jun 1998
Liang M H, Wong L J
Abstract excerpt
The multiplex polymerase chain reaction-allele specific oligonucleotides (PCR/ASO) dot blot hybridization method was used to detect 44 mitochondrial DNA point mutations in 2,000 patients suspected as having mitochondrial DNA disorders. These point mutations are classified into four categories. Category I consists of primary disease-causing, heteroplasmic point mutations. Homoplasmic nucleotide substitutions that...
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