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Analysis of common mitochondrial DNA mutations by allele-specific oligonucleotide and Southern blot hybridization.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Tang Sha, Halberg Michelle C, Floyd Kristen C, Wang Jing

Abstract excerpt

Mitochondrial disorders are clinically and genetically heterogeneous. There are a set of recurrent point mutations in the mitochondrial DNA (mtDNA) that are responsible for common mitochondrial diseases, including MELAS (mitochondrial encephalopathy, lactic acidosis, stroke-like episodes), MERRF (myoclonic epilepsy and ragged red fibers), LHON (Leber's hereditary optic neuropathy), NARP (neuropathy, ataxia,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22215554
DOI: 10.1007/978-1-61779-504-6_18

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