Article
Diagnosis of sickle-cell disease by DNA analysis in Nigeria.
The Central African journal of medicine - 1 Dec 1997
Adewole T A, Olukoya D K, Afonja A
Abstract excerpt
OBJECTIVE: To compare genotyping of leucocyte DNA by PCR and Dde I with the conventional genotyping of haemoglobin of the same subject. DESIGN: Comparative study. SUBJECTS: 25 adults, 16 males and nine females. MAIN OUTCOME MEASURES: Predictability. RESULTS: In all cases the results were comparable. CONCLUSIONS: The technology can be applied locally to prenatal diagnosis of sickle-cell disease by chorionic...
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