Application of polymerase chain reaction to the prenatal diagnosis of sickle cell anaemia in Nigeria.

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Article

Application of polymerase chain reaction to the prenatal diagnosis of sickle cell anaemia in Nigeria.

West African journal of medicine - 1 Jan 2000

Adewole T A, Olukosi Y A, Disu F, Akinde J A, Emuveyan E, Adesemoye E, Akinyanju O O, Afonja O A

Abstract excerpt

Although sickle-cell disease is very common in Nigeria, control by prenatal testing is lacking. The polymerase chain reaction-based technology combined with chorionic villi sampling has enabled us to offer prenatal diagnosis of sickle cell disease to 50 pregnant women who were at risk of bearing children with sickle cell anaemia. DNA was extracted from the villus and subjected to either PCR and restriction enzyme...

Topics

Adult
Anemia, Sickle Cell
Chorionic Villi Sampling
Female
Genetic Testing
Genotype
Humans
Middle Aged
Nigeria
Pilot Projects
Polymerase Chain Reaction
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second

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PMID: 10593149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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