Article
Correlation between cell cycle regulators and the immortalization and transformation of human breast epithelial cell lines.
International journal of oncology - 1 Jul 1998
Salicioni A M, Russo I H, Russo J
Abstract excerpt
Cellular proliferation, essential for normal development, may result in neoplastic growth when the cell cycle clock is disrupted. In order to determine whether the protein expression of cell cycle regulators differs among normal, immortalized non-tumorigenic and malignant human breast epithelial cells (HBECs), we analyzed the protein expression of cyclins D1, D3, A and E, cyclin-dependent kinase (cdk) 4 and c-fos...
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