Article
Phenotype-related differences in the expression of D-type cyclins in human B cell-derived lines.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1996
Pokrovskaja K, Ehlin-Henriksson B, Bartkova J, Bartek J, Scuderi R, Szekely L, Wiman K G, Klein G
Abstract excerpt
Exposure of normal resting B lymphocytes to EBV in vitro leads to activation, subsequent immortalization, and the establishment of lymphoblastoid cell lines (LCLs). The endemic form of Burkitt's lymphoma (BL) is associated with EBV. EBV-positive BL lines maintain the original tumor phenotype (group I BL) initially and express only one EBV-encoded protein, EBV nuclear antigen (EBNA)-1. Most of them drift toward a...
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