Article
Molecular evidence for multifocal papillary serous carcinoma of the peritoneum in patients with germline BRCA1 mutations.
Journal of the National Cancer Institute - 3 Jun 1998
Schorge J O, Muto M G, Welch W R, Bandera C A, Rubin S C, Bell D A, Berkowitz R S, Mok S C
Abstract excerpt
BACKGROUND: Papillary serous carcinoma of the peritoneum (PSCP) diffusely involves peritoneal surfaces, while it spares or only superficially involves the ovaries. PSCP is histologically indistinguishable from serous epithelial ovarian carcinoma, and it may develop years after oophorectomy. The molecular pathogenesis of PSCP remains unresolved, although preliminary data suggest a multifocal origin in some cases....
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