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Article

Hemoglobin Raleigh as the cause of a falsely increased hemoglobin A1C in an automated ion-exchange HPLC method.

Clinical chemistry - 1 Jun 1998

Chen D, Crimmins D L, Hsu F F, Lindberg F P, Scott M G

Abstract excerpt

Irreversible glycation of the hemoglobin A0 (HbA0) beta chain leads to the production of HbA1C, which can be used to monitor long-term blood glucose control in patients with diabetes mellitus. HbA1C is less positively charged than nonglycated HbA0, and this decrease in charge is the basis of ion-exchange and electrophoretic methods that measure HbA1C. We recently identified a sample that appeared to contain 46%...

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Source

Identifiers

PMID: 9625056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hemoglobin Raleigh as the cause of a falsely increased hemoglobin A1C in an automated ion-exchange HPLC method.PMID 9625056Read ↗

Two novel haemoglobin variants that affect haemoglobin A1c measurement by ion-exchange chromatography.Semantic proximity Read ↗

Spuriously high HbA1c due to the presence of haemoglobin Raleigh: a case report and review of the literature.Semantic proximity Read ↗

A spurious haemoglobin A(1c) result associated with double heterozygote for haemoglobin Raleigh (β1[NA1]Val → Ala) and α(+)-thalassaemia.Semantic proximity Read ↗

Silent hemoglobin variants and determination of HbA(1c) with the high-resolution program of the HPLC HA-8160 hemoglobin analyzer.Semantic proximity Read ↗

Unintended reporting of misleading Hb A(1c) values when using assays incapable of detecting hemoglobin variants.Semantic proximity Read ↗

[Importance of the characteristics of the chromatographic separation in HPLC for the interpretation of HbA1c assay in the presence of a variant hemoglobin].Semantic proximity Read ↗

Identification of a new hemoglobin variant Hb Liuzhou [HBA1:C.182A→G] by MALDI-TOF mass spectrometry during HbA1c measurement.Semantic proximity Read ↗

Determination of glycated hemoglobin in clinically silent hemoglobin variants.Semantic proximity Read ↗

Hemoglobin variant HbG-coushatta (beta-22 Glu --> Ala) found by dissociation of blood glucose from values of HbA1C measured by HPLC.Semantic proximity Read ↗

Unexpected HbA1c results in the presence of three rare hemoglobin variants.Semantic proximity Read ↗

Hb Belluno [β111(G13)Val→Gly;β133(H11)Val→Val (HBB: c.335T > G;402G > C)]: Incidental Detection of a New Clinically Silent β Chain Variant During Hb A1c Determination by High Performance Liquid Chromatography.Semantic proximity Read ↗

[Interest of the study of a not identified peak on a hemoglobin chromatogram: delta variant or inter-sample contaminations?].Semantic proximity Read ↗

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