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Article

Two novel haemoglobin variants that affect haemoglobin A1c measurement by ion-exchange chromatography.

Clinical chemistry and laboratory medicine - 1 Aug 2015

Bots Michael, Stroobants An K, Delzenne Barend, Soeters Maarten R, de Vries Johan E, Weykamp Cas W, Norg Roelf J C, Veldthuis Martijn, Zwieten Rob van

Abstract excerpt

BACKGROUND: Haemoglobin (Hb) variants are well-known factors interfering with accurate HbA1c testing. This report describes two novel Hb variants leading to inappropriate quantification of HbA1c by ion-exchange chromatography. METHODS: Glycated forms of novel Hb variants were recognised in the blood of two patients with diabetes mellitus screened by HbA1c ion-exchange chromatography. Dedicated high-resolution...

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Share to Blood Chemical Analysis
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, Ion Exchange

Share to HBA1 gene

Share to HBB gene

Share to Glycated Hemoglobin

Share to Hemoglobins, Abnormal

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Source

Identifiers

PMID: 26035110
DOI: 10.1515/cclm-2015-0054

Genes

HBA1
HBB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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