Article
HLA-DR typing of women with recurrent late spontaneous abortion and unsuccessful cervical cerclage.
Human reproduction (Oxford, England) - 1 Apr 1998
Mohapeloa H, Christiansen O B, Grunnet N
Abstract excerpt
The release of certain cytokines, e.g. tumour necrosis factor (TNF)-alpha, in the amniotic fluid has been suggested to be a cause of preterm birth. The predisposition to excessive liberation of cytokines from peripheral leukocytes has been shown to depend partly on the individual's HLA-DR genotype. The HLA-DR1 and -DR3 alleles have previously been reported as being associated with a TNF-alpha high responder...
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