Article
The genetically programmed down-regulation of lactase in children.
Gastroenterology - 1 Jun 1998
Wang Y, Harvey C B, Hollox E J, Phillips A D, Poulter M, Clay P, Walker-Smith J A, Swallow D M
Abstract excerpt
BACKGROUND & AIMS: Intestinal lactase activity is high in all healthy human babies, but in adults a genetic polymorphism, which acts in cis to the lactase gene, determines high or low messenger RNA (mRNA) expression and activity (lactase persistence and nonpersistence, respectively). Our aim was...
Topics
- Adolescent
- Adult
- Alleles
- Biopsy
- Child
- Child Development
- Child, Preschool
- Fetus
- Gene Expression Regulation
- Humans
- Infant
- Infant, Newborn
- Intestines
- Lactase
- Polymorphism, Genetic
- Prospective Studies
- RNA, Messenger
- Reference Values