Article
Effect of C/T -13910 cis-acting regulatory variant on expression and activity of lactase in Indian children and its implication for early genetic screening of adult-type hypolactasia.
Clinica chimica acta; international journal of clinical chemistry - 9 Oct 2011
Kuchay Raja A H, Thapa Babu R, Mahmood Akhtar, Mahmood Safrun
Abstract excerpt
BACKGROUND: Absorption of milk sugar (lactose) is regulated by the activity of lactase enzyme in gut wall. Intestinal lactase activity declines during childhood in majority of human populations leading to adult-type hypolactasia (primary lactose malabsorption), limiting the use of fresh milk due to lactose intolerance. Aim of this study was to correlate lactase expression and activity with C/T -13910 variant in...
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