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Article

Human cytomegalovirus down-regulates HLA class I expression by reducing the stability of class I H chains.

1 Nov 1993

Abstract excerpt

Human CMV (HCMV) infection leads to an almost complete inhibition of expression of MHC class I proteins. After infection with HCMV, the biosynthesis of HLA class I molecules was examined in human lung fibroblasts and in mouse fibroblasts transfected with genes encoding the human class I H chain HLA-B27 and human beta 2-microglobulin (beta 2m). In both cell types, we observed a large decrease in steady state...

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Identifiers

PMID: 8409412
DOI: 10.4049/jimmunol.151.9.4455

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