Article
New paradigms for the treatment of pediatric monogenic epilepsies: Progressing toward precision medicine.
Epilepsy & behavior : E&B - 1 Jun 2022
Specchio Nicola, Pietrafusa Nicola, Perucca Emilio, Cross J Helen
Abstract excerpt
Despite the availability of 28 antiseizure medications (ASMs), one-third of people with epilepsy fail to achieve sustained freedom from seizures. Clinical outcome is even poorer for children with developmental and epileptic encephalopathies (DEEs), many of which are due to single-gene mutations. Discovery of causative genes, however, has paved the way to understanding the molecular mechanism underlying these...
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