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Article

Carcinoembryonic Antigen Family Receptor Recognition by Gonococcal Opa Proteins Requires Distinct Combinations of Hypervariable Opa Protein Domains

1 Apr 2002

Abstract excerpt

Neisserial Opa proteins function as a family of adhesins that bind heparan sulfate proteoglycan (HSPG) or carcinoembryonic antigen family (CEACAM) receptors on human host cells. In order to define the CEACAM binding domain on Opa proteins, we tested the binding properties of a series of gonococcal (strain MS11) recombinants producing mutant and chimeric Opa proteins with alterations in one or more of the four...

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Identifiers

PMID: 11895933
DOI: 10.1128/iai.70.4.1715-1723.2002

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Source receipt: pubmed, retrieved 7 Sept 2026.

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