Article
Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells.
PloS one - 1 Jan 2016
Vacca Irene, Del Tordello Elena, Gasperini Gianmarco, Pezzicoli Alfredo, Di Fede Martina, Rossi Paccani Silvia, Marchi Sara, Mubaiwa Tsisti D, Hartley-Tassell Lauren E, Jennings Michael P, Seib Kate L, Masignani Vega, Pizza Mariagrazia, Serruto Davide, Aricò Beatrice, Delany Isabel
Abstract excerpt
Neisserial Heparin Binding Antigen (NHBA) is a surface-exposed lipoprotein ubiquitously expressed by Neisseria meningitidis strains and an antigen of the Bexsero® vaccine. NHBA binds heparin through a conserved Arg-rich region that is the target of two proteases, the meningococcal NalP and human lactoferrin (hLf). In this work, in vitro studies showed that recombinant NHBA protein was able to bind epithelial...
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