Article
Systematic search for mutations in the 14-3-3 eta chain gene on chromosome 22 in schizophrenics.
Psychiatric genetics - 1 Jan 1998
Hayakawa T, Ishiguro H, Toru M, Hamaguchi H, Arinami T
Abstract excerpt
The brain-rich 14-3-3 protein regulates synthesis and excretion of bioamine by activating tyrosine and tryptophan hydroxylases, and by exocytosis of catecholamines and serotonin. In humans, at least eight subunits of the 14-3-3 protein family have been isolated. The 14-3-3 eta chain gene is located at 22q12.1 to q13.1, one of the chromosome regions identified as possibly linked to schizophrenia. We systematically...
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