Article
Expression of interferon receptor genes (IFNAR1 and IFNAR2 mRNA) in the liver may predict outcome after interferon therapy in patients with chronic genotype 2a or 2b hepatitis C virus infection.
Journal of clinical gastroenterology - 1 Mar 1998
Morita K, Tanaka K, Saito S, Kitamura T, Kondo M, Sakaguchi T, Morimoto M, Sekihara H
Abstract excerpt
Hepatitis C virus (HCV) genotype 2a or 2b is associated with a favorable outcome after interferon therapy. However, 19% to 33% of patients do not respond to therapy. We investigated whether interferon receptor gene (IFNAR1 and IFNAR2 mRNA) expression in the liver before interferon therapy predict...
Topics
- Adult
- Aged
- DNA Primers
- Enzyme-Linked Immunosorbent Assay
- Female
- Follow-Up Studies
- Genotype
- Hepacivirus
- Hepatitis C Antibodies
- Hepatitis C, Chronic
- Humans
- Interferon-alpha
- Male
- Membrane Proteins
- Middle Aged