Article
Plasmodium falciparum: in vitro chloroquine susceptibility and allele-specific PCR detection of Pfmdr1 Asn86Tyr polymorphism in Lambarene, Gabon.
Parasitology - 1 Mar 1998
Grobusch M P, Adagu I S, Kremsner P G, Warhurst D C
Abstract excerpt
Plasmodium falciparum resistance to chloroquine has been described in many parts of the world particularly in Africa where malaria is endemic. High levels of chloroquine resistance in our study area, Lambarene-Gabon, has led to the use of an alternative regimen for treatment and prevention of P. falciparum infection. In this study, we examined the in vitro chloroquine sensitivity of 15 isolates from this area and...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antimalarials
- Biomarkers
- Chloroquine
- Codon
- DNA Primers
- Dose-Response Relationship, Drug
- Drug Resistance
- Electrophoresis, Agar Gel