Article
[Ionic binding of 3H-gentamicin and short-term bactericidal activity of gentamicin against Pseudomonas aeruginosa isolates differing in lipopolysaccharide structure].
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases - 1 Feb 1998
Saika T, Hasegawa M, Kobayashi I, Nishida M
Abstract excerpt
The clinical isolates of Pseudomonas aeruginosa can be roughly classified into long- and short-lipopolysaccharide (LPS) strains and LPS-deficient strains, based on the silver-stained patterns of their LPSs after SDS-PAGE. The ionic binding of 3H-gentamicin, a polycationic antibiotic, to the negatively charged sites on the surface structures of P. aeruginosa strains, often differing in LPS structure, was the...
Topics
- Anti-Bacterial Agents
- Gentamicins
- Mutation
- Polysaccharides, Bacterial
- Pseudomonas aeruginosa
- Tritium