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Article

Structural alterations in the envelope of a gentamicin-resistant rough mutant of Pseudomonas aeruginosa.

Annales de microbiologie - 1 Jan 2000

Galbraith L, Wilkinson S G, Legakis N J, Genimata V, Katsorchis T A, Rietschel E T

Abstract excerpt

Comparative studies of a gentamicin-sensitive strain (P28-0) of Pseudomonas aeruginosa and a gentamicin-resistant mutant (P23-800) have been carried out. No aminoglycoside-modifying enzymes were detected in extracts of the mutant. Electron microscopy of thin sections and the loss of O-antigenicity suggested that resistance of the mutant to gentamicin was related to an alteration in the outer membrane. Analysis of...

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PMID: 6439097
DOI: 10.1016/s0769-2609(84)80020-4

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