Combined effect of two different polymorphic sequences within the beta globin gene cluster on the level of HbF.

doi:10.1002/(sici)1096-8652(199804)57:4<269::aid-ajh1>3.0.co;2-s

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Article

Combined effect of two different polymorphic sequences within the beta globin gene cluster on the level of HbF.

American journal of hematology - 1 Apr 1998

Gonçalves I, Ducrocq R, Lavinha J, Nogueira P J, Peres M J, Picanço I, Correia E, Reis A B, Silva C, Krishnamoorthy R, Almeida L O

Abstract excerpt

Beta thalassemia and Hb Lepore heterozygotes included in this study exhibit fetal hemoglobin levels varying from trace quantities to 14% (1.74 g/dl) of total hemoglobin in the adult. In this work, we have examined the correlation of DNA sequence polymorphisms with the observed HbF level. The analysis of polymorphic markers within the beta globin cluster in 39 individuals heterozygous for beta thalassemia or Hb...

Topics

Adolescent
Adult
Aged
Alleles
Child, Preschool
Female
Fetal Hemoglobin
Gene Expression Regulation
Globins
Haplotypes
Hemoglobinopathies
Hemoglobins, Abnormal
Humans
Male

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Pedigree

Polymorphism, Restriction Fragment Length

beta-Thalassemia

Source

Open in PubMed

Identifiers

PMID: 9544969
DOI: 10.1002/(sici)1096-8652(199804)57:4<269::aid-ajh1>3.0.co;2-s

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