Evidence for keratinocyte stem cells in vitro : Long term engraftment and persistence of transgene expression from retrovirus-transduced keratinocytes

Abstract excerpt

Epidermis is renewed by a population of stem cells that have been defined in vivo by slow turnover, label retention, position in the epidermis, and enrichment in beta1 integrin, and in vitro by clonogenic growth, prolonged serial passage, and rapid adherence to extracellular matrix. The goal of this study is to determine whether clonogenic cells with long-term growth potential in vitro persist in vivo and give...

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