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Article

Long-term homeostasis and wound healing in an in vitro epithelial stem cell niche model

24 Feb 2017

Abstract excerpt

Cultures of epithelial cells are limited by the proliferative capacity of primary cells and cell senescence. Herein we show that primary human epithelial cell sheets cultured without dermal equivalents maintained homeostasis in vitro for at least 1 year. Transparency of these sheets enabled live observation of pigmented melanocytes and Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI) labeled...

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PMID: 28233843
DOI: 10.1038/srep43557

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