Article
Altered membrane structure and surface potential in homozygous hemoglobin C erythrocytes.
PloS one - 8 Jun 2009
Tokumasu Fuyuki, Nardone Glenn A, Ostera Graciela R, Fairhurst Rick M, Beaudry Steven D, Hayakawa Eri, Dvorak James A
Abstract excerpt
BACKGROUND: Hemoglobin C differs from normal hemoglobin A by a glutamate-to-lysine substitution at position 6 of beta globin and is oxidatively unstable. Compared to homozygous AA erythrocytes, homozygous CC erythrocytes contain higher levels of membrane-associated hemichromes and more extensively clustered band 3 proteins. These findings suggest that CC erythrocytes have a different membrane matrix than AA...
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