Article
Atypical splicing of the latency-associated transcripts of herpes simplex type 1.
Virology - 30 Mar 1998
Wu T T, Su Y H, Block T M, Taylor J M
Abstract excerpt
We previously have shown that two latency-associated transcripts (LATs) of herpes simplex type 1 (HSV-1) are probably lariats, produced during splicing. By RNaseH digestion analysis, we now show that the major branchpoint of the 2.0-kb LAT was within 46 nt 5' of the splice acceptor site. A more detailed mapping by primer extension revealed the branchpoint as an adenosine 29 nt 5' of the splice acceptor site....
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