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Article

Activation of alpha6-containing GABAA receptors by pentobarbital occurs through a different mechanism than activation by GABA.

Neuroscience letters - 8 Mar 2010

Fisher Matthew T, Fisher Janet L

Abstract excerpt

The GABA(A) receptors are ligand-gated chloride channels which are the targets for many clinically used sedatives, including the barbiturates. The barbiturate pentobarbital acts through multiple sites on the GABA(A) receptor. At low concentrations (muM), it acts as a positive allosteric modulator...

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Identifiers

PMID: 20109529
DOI: 10.1016/j.neulet.2010.01.041
PMCID: PMC3652006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20109529-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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