Tropism for primary monocytes and for monocytoid cell lines are separate features of HIV-1 variants.

doi:10.1002/jlb.56.3.225

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Article

Tropism for primary monocytes and for monocytoid cell lines are separate features of HIV-1 variants.

Journal of leukocyte biology - 1 Sept 1994

Valentin A, Nilsson K, Asjö B

Abstract excerpt

We have analyzed the phenotype of five human monocytoid cell lines (U-937, THP-1, RC.2A, Mono Mac 6, and DD) and their capacity to support replication of HIV-1 strains with known tropism for T lymphocytes and mononuclear phagocytes. HIV-1 Ba-L, a prototype monocytotropic HIV-1 strain, was unable to establish continuous replication in any of the cell lines used. In contrast, the lymphotropic strain IIIB could...

Topics

Acquired Immunodeficiency Syndrome
Cell Line
Cell Movement
Cytokines
Fluorescent Antibody Technique
HIV-1
Humans
In Vitro Techniques
Leukemia, Monocytic, Acute
Leukemia, Myelomonocytic, Acute
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoma, Large B-Cell, Diffuse

Monocytes

Phagocytes

Phenotype

T-Lymphocytes

Tumor Cells, Cultured

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 8083593
DOI: 10.1002/jlb.56.3.225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8083593-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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