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Article

The quantity of latent viral DNA correlates with the relative rates at which herpes simplex virus types 1 and 2 cause recurrent genital herpes outbreaks.

Journal of virology - 1 Apr 1998

Lekstrom-Himes J A, Pesnicak L, Straus S E

Abstract excerpt

Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) have evolved specific anatomic tropisms and site-dependent rates of reactivation. To determine whether reactivation rates depend on distinct abilities of HSV-1 and -2 to establish latency and to express latency-associated transcripts (LATs), virulent strains of each virus were studied in the guinea pig genital model. Following infection with equivalent titers...

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Identifiers

PMID: 9525595
DOI: 10.1128/JVI.72.4.2760-2764.1998
PMCID: PMC109720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The quantity of latent viral DNA correlates with the relative rates at which herpes simplex virus types 1 and 2 cause recurrent genital herpes outbreaks.PMID 9525595Read ↗

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The characteristic site-specific reactivation phenotypes of HSV-1 and HSV-2 depend upon the latency-associated transcript region.Semantic proximity Read ↗

Latency-associated transcript (LAT) exon 1 controls herpes simplex virus species-specific phenotypes: reactivation in the guinea pig genital model and neuron subtype-specific latent expression of LAT.Semantic proximity Read ↗

Recurrent genital infection in the guinea pig: differences between herpes simplex types 1 and 2.Semantic proximity Read ↗

Herpes Simplex Virus 2 Latency-Associated Transcript (LAT) Region Mutations Do Not Identify a Role for LAT-Associated MicroRNAs in Viral Reactivation in Guinea Pig Genital Models.Semantic proximity Read ↗

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The herpes simplex virus type 1 latency associated transcript locus is required for the maintenance of reactivation competent latent infections.Semantic proximity Read ↗

Quantitation of herpes simplex virus type 1 DNA and latency-associated transcripts in rabbit trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latencySemantic proximity Read ↗

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