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Article

Gene rearrangement attenuates expression and lethality of a nonsegmented negative strand RNA virus

31 Mar 1998

Abstract excerpt

The nonsegmented negative strand RNA viruses comprise hundreds of human, animal, insect, and plant pathogens. Gene expression of these viruses is controlled by the highly conserved order of genes relative to the single transcriptional promoter. We utilized this regulatory mechanism to alter gene expression levels of vesicular stomatitis virus by rearranging the gene order. This report documents that gene...

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PMID: 9520395
DOI: 10.1073/pnas.95.7.3501

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