Article
Transcriptional analysis of the EhPgp5 promoter of Entamoeba histolytica multidrug-resistant mutant.
The Journal of biological chemistry - 27 Mar 1998
Pérez D G, Gómez C, López-Bayghen E, Tannich E, Orozco E
Abstract excerpt
We report here the cloning and transcriptional characterization of the EhPgp5 multidrug resistance gene promoter isolated from the drug-resistant clone C2 of Entamoeba histolytica. The EhPgp5 promoter has the TATA-like motif at -31 base pairs; transcription initiates three nucleotides upstream from the ATG in trophozoites grown in 225 microM emetine (clone C2(225)), whereas in those grown without the drug (clone...
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