Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EhPgp5 mRNA stability is a regulatory event in the Entamoeba histolytica multidrug resistance phenotype.

The Journal of biological chemistry - 28 Mar 2003

López-Camarillo César, Luna-Arias Juan Pedro, Marchat Laurence A, Orozco Esther

Abstract excerpt

The multidrug resistance (MDR) phenotype in Entamoeba histolytica is characterized by the overexpression of the EhPgp5 gene in trophozoites grown in high drug concentrations. Here we evaluated the role of EhPgp5 mRNA stability on MDR using actinomycin D. EhPgp5 mRNA from trophozoites growing without emetine had a half-life of 2.1 h, which augmented to 3.1 h in cells cultured with 90 microM and to 7.8 h with 225...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
Share to Dactinomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

Share to Entamoeba histolytica

Share to Genes, Protozoan

Share to Protozoan Proteins

Share to Sequence Homology, Nucleic Acid

Share to Transcription, Genetic

Source

Identifiers

PMID: 12556531
DOI: 10.1074/jbc.M211757200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EhPgp5 mRNA stability is a regulatory event in the Entamoeba histolytica multidrug resistance phenotype.PMID 12556531Read ↗

Transcriptional analysis of the EhPgp5 promoter of Entamoeba histolytica multidrug-resistant mutant.Semantic proximity Read ↗

The multidrug-resistance phenotype of Entamoeba histolytica-transfected trophozoites with the EhPgp5 gene.Semantic proximity Read ↗

Targeting the polyadenylation factor EhCFIm25 with RNA aptamers controls survival in Entamoeba histolyticaSemantic proximity Read ↗

Robust gene silencing mediated by antisense small RNAs in the pathogenic protist Entamoeba histolyticaSemantic proximity Read ↗

Eukaryotic translation initiation factor 5A and its hypusination play an important role in proliferation and differentiation of the human enteric protozoan parasite <i>Entamoeba histolytica</i>Semantic proximity Read ↗

Growth of the protozoan parasite Entamoeba histolytica in 5-azacytidine has limited effects on parasite gene expressionSemantic proximity Read ↗

Nucleus-localized Antisense Small RNAs with 5′-Polyphosphate Termini Regulate Long Term Transcriptional Gene Silencing in Entamoeba histolytica G3 StrainSemantic proximity Read ↗

Use of bacterially expressed dsRNA to downregulate Entamoeba histolytica gene expression.Semantic proximity Read ↗

The Abundant Polyadenylated Transcript 2 DNA Sequence of the Pathogenic Protozoan Parasite Entamoeba histolytica Represents a Nonautonomous Non-Long-Terminal-Repeat Retrotransposon- Like Element Which Is Absent in the Closely Related Nonpathogenic Species Entamoeba disparSemantic proximity Read ↗

Pleiotropic phenotype in Entamoeba histolytica overexpressing DNA methyltransferase (Ehmeth).Semantic proximity Read ↗

Transcriptional Silencing of Multiple Genes in Trophozoites of Entamoeba histolyticaSemantic proximity Read ↗

Differential Mechanisms for the Involvement of Polyamines and Hypusinated eIF5A in Ebola Virus Gene ExpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.