Article
New AUG initiation codons in a long 5' UTR create four dominant negative alleles of the Drosophila C2H2 zinc-finger gene ovo.
Development genes and evolution - 1 Jan 1998
Andrews J, Levenson I, Oliver B
Abstract excerpt
Promoters active in the germline produce OVO-A and OVO-B mRNAs encoding isoforms of a putative transcription factor. The isoforms have a common C2H2 zinc-finger domain but different N-termini that include potential effector domains. Single point mutations in three dominant-negative ovoD mutations result in new in-frame initiation codons in OVO-B mRNAs and amino acid substitutions within charged regions of OVO-A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
