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Article

The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4.

Development (Cambridge, England) - 1 Apr 1998

Hudson J B, Podos S D, Keith K, Simpson S L, Ferguson E L

Abstract excerpt

The Transforming Growth Factor-beta superfamily member decapentaplegic (dpp) acts as an extracellular morphogen to pattern the embryonic ectoderm of the Drosophila embryo. To identify components of the dpp signaling pathway, we screened for mutations that act as dominant maternal enhancers of a weak allele of the dpp target gene zerknŁllt. In this screen, we recovered new alleles of the Mothers against dpp (Mad)...

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Source

Identifiers

PMID: 9502722
DOI: 10.1242/dev.125.8.1407

Genes

SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4.PMID 9502722Read ↗

Characterization of Medea, a gene required for maximal function of the Drosophila BMP homolog Decapentaplegic.Semantic proximity Read ↗

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.Semantic proximity Read ↗

Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.Semantic proximity Read ↗

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.Semantic proximity Read ↗

Analysis of the shortvein cis-regulatory region of the decapentaplegic gene of Drosophila melanogaster.Semantic proximity Read ↗

Genetic screen for regulators of ind expression identifies shrew as encoding a novel twisted gastrulation-like protein involved in Dpp signaling.Semantic proximity Read ↗

Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo.Semantic proximity Read ↗

Target genes of Dpp/BMP signaling pathway revealed by transcriptome profiling in the early D.melanogaster embryo.Semantic proximity Read ↗

The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp.Semantic proximity Read ↗

Drosophila Med6 is required for elevated expression of a large but distinct set of developmentally regulated genes.Semantic proximity Read ↗

Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development.Semantic proximity Read ↗

Dishevelled: in vivo roles of a multifunctional gene family during development.Semantic proximity Read ↗

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