Article
The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4.
Development (Cambridge, England) - 1 Apr 1998
Hudson J B, Podos S D, Keith K, Simpson S L, Ferguson E L
Abstract excerpt
The Transforming Growth Factor-beta superfamily member decapentaplegic (dpp) acts as an extracellular morphogen to pattern the embryonic ectoderm of the Drosophila embryo. To identify components of the dpp signaling pathway, we screened for mutations that act as dominant maternal enhancers of a w...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosome Mapping
- Cloning, Molecular
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Embryo, Nonmammalian
- Female
- Genes, Insect
- Genes, Lethal
- Genes, Tumor Suppressor
- Heterozygote
- Humans
- Insect Proteins
- Male
- Molecular Sequence Data