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Article

The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.

The EMBO journal - 10 Aug 1998

Lorenz M C, Heitman J

Abstract excerpt

In response to nitrogen starvation, diploid cells of the budding yeast Saccharomyces cerevisiae differentiate into a filamentous, pseudohyphal growth form. This dimorphic transition is regulated by the Galpha protein GPA2, by RAS2, and by elements of the pheromone-responsive MAP kinase cascade, yet the mechanisms by which nitrogen starvation is sensed remain unclear. We have found that MEP2, a high affinity...

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Identifiers

PMID: 9482721
DOI: 10.1093/emboj/17.5.1236
PMCID: PMC1170472

Genes

NPR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae.PMID 9482721Read ↗

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Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains.Semantic proximity Read ↗

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Transcript and proteomic analyses of wild-type and gpa2 mutant Saccharomyces cerevisiae strains suggest a role for glycolytic carbon source sensing in pseudohyphal differentiation.Semantic proximity Read ↗

Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast.Semantic proximity Read ↗

Pseudohyphal differentiation defect due to mutations in GPCR and ammonium signaling is suppressed by low glucose concentration: a possible integrated role for carbon and nitrogen limitation.Semantic proximity Read ↗

Isolation and characterization from pathogenic fungi of genes encoding ammonium permeases and their roles in dimorphism.Semantic proximity Read ↗

The Mep2p ammonium permease controls nitrogen starvation-induced filamentous growth in Candida albicans.Semantic proximity Read ↗

Ime1 and Ime2 are required for pseudohyphal growth of Saccharomyces cerevisiae on nonfermentable carbon sources.Semantic proximity Read ↗

The Saccharomyces cerevisiae mutation elm4-1 facilitates pseudohyphal differentiation and interacts with a deficiency in phosphoribosylpyrophosphate synthase activity to cause constitutive pseudohyphal growth.Semantic proximity Read ↗

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