Article
GDNF deficit in Hirschsprung's disease.
Journal of pediatric surgery - 1 Jan 1998
Martucciello G, Thompson H, Mazzola C, Morando A, Bertagnon M, Negri F, Brizzolara A, Rocchetti L, Gambini C, Jasonni V
Abstract excerpt
BACKGROUND/PURPOSE: In 1996, the glial cell line-derived neurotrophic factor (GDNF) was identified as one of the ligands of the RET transmembrane receptor. In the same year, GDNF mutations were found in association with RET protooncogene mutations in Hirschsprung patients. Mutations in GDNF per se are thought neither necessary nor sufficient to cause Hirschsprung's disease (HD). To date, our study group has...
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