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Two-step oligoclonal development of male germ cells

19 Dec 2008

Abstract excerpt

During mouse development, primordial germ cells (PGCs) that give rise to the entire germ line are first identified within the proximal epiblast. However, long-term tracing of the fate of the cells has not been done wherein all cells in and around the germ-cell lineage are identified. Also, quantitative estimates of the number of founder PGCs using different models have come up with various numbers. Here, we use...

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PMID: 19098099
DOI: 10.1073/pnas.0810325105

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