Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Cloning and Expression of a Purine-specific N-Ribohydrolase from Trypanosoma brucei brucei

1 Jan 1998

Abstract excerpt

N-Ribohydrolases, including the inosine-adenosine-guanosine-preferring (IAG) nucleoside hydrolase, have been proposed to be involved in the nucleoside salvage pathway of protozoan parasites and may constitute rational therapeutic targets for the treatment of these diseases. Reported is the complete sequence of the Trypanosoma brucei brucei iagnh gene, which encodes IAG-nucleoside hydrolase. The 1.4-kilobase iagnh...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to Peptidase Inhibition and Analysis
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9442052
DOI: 10.1074/jbc.273.4.2118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Cloning and Expression of a Purine-specific N-Ribohydrolase from Trypanosoma brucei bruceiPMID 9442052Read ↗

Characterization of adenine phosphoribosyltransferase (APRT) activity in <i>Trypanosoma brucei brucei</i> : Only one of the two isoforms is kinetically activeSemantic proximity Read ↗

Targeting the nucleotide metabolism of Trypanosoma brucei and other trypanosomatidsSemantic proximity Read ↗

Uridine-ribohydrolase is a key regulator in the uridine degradation pathway of Arabidopsis.Semantic proximity Read ↗

Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei bruceiSemantic proximity Read ↗

Mapping the transporter-substrate interactions of the Trypanosoma cruzi NB1 nucleobase transporter reveals the basis for its high affinity and selectivity for hypoxanthine and guanine and lack of nucleoside uptakeSemantic proximity Read ↗

Purine Salvage Pathways in the Apicomplexan Parasite Toxoplasma gondiiSemantic proximity Read ↗

Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.Semantic proximity Read ↗

Purine and pyrimidine transport in pathogenic protozoa: From biology to therapySemantic proximity Read ↗

Inhibitors of the Purine Salvage Pathway: A Valuable Approach for Antiprotozoal Chemotherapy?Semantic proximity Read ↗

RNA interference in protozoan parasitesSemantic proximity Read ↗

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6Semantic proximity Read ↗

Molecular characterization and overexpression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma cruziSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.