Evidence for cyclophosphamide-induced gene conversion and mutation in mouse germ cells.

doi:10.1006/taap.1997.8292

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Article

Evidence for cyclophosphamide-induced gene conversion and mutation in mouse germ cells.

Toxicology and applied pharmacology - 1 Dec 1997

Schimenti K J, Hanneman W H, Schimenti J C

Abstract excerpt

Cyclophosphamide (CP) is a widely used antineoplastic drug. It tests positive in several genotoxicity assays, including those with endpoints such as chromosomal aberrations in mammalian cells, mitotic recombination in Drosophila melanogaster, and dominant lethal mutations in rodents. We have expl...

Topics

Animals
Cell Line
Cyclophosphamide
Dose-Response Relationship, Drug
Gene Conversion
Male
Mice
Mice, Transgenic
Mutagens
Mutation
Spermatozoa

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