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Article

Evidence for cyclophosphamide-induced gene conversion and mutation in mouse germ cells.

Toxicology and applied pharmacology - 1 Dec 1997

Schimenti K J, Hanneman W H, Schimenti J C

Abstract excerpt

Cyclophosphamide (CP) is a widely used antineoplastic drug. It tests positive in several genotoxicity assays, including those with endpoints such as chromosomal aberrations in mammalian cells, mitotic recombination in Drosophila melanogaster, and dominant lethal mutations in rodents. We have explored the effects of CP on genome stability of mouse (Mus domesticus) spermatogenic cells, using a recombination-based...

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Identifiers

PMID: 9439729
DOI: 10.1006/taap.1997.8292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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