Article
Cat3vl and Cat3vao cataract mutations on mouse chromosome 10: phenotypic characterization, linkage studies and analysis of candidate genes.
Molecular & general genetics : MGG - 1 Dec 1997
Löster J, Immervoll T, Schmitt-John T, Graw J
Abstract excerpt
Cat3vl and Cat3vao are two allelic, dominant cataract mutations that arose independently in the F1 generation after gamma-irradiation of male mice. The cataracts are already present at birth. Examination of the eyes with a slit lamp revealed completely vacuolated lenses in Cat3vl mutants and ante...
Topics
- Animals
- Cataract
- Chondroitin Sulfate Proteoglycans
- Chromosomes
- Decorin
- Extracellular Matrix Proteins
- Genes, Dominant
- Genetic Linkage
- Genetic Markers
- Keratan Sulfate
- Lumican
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred Strains
- Mice, Mutant Strains
- Mutation
- Phenotype