Cell-associated activation of latent transforming growth factor-β by calpain

Abstract excerpt

Transforming growth factor-beta (TGF-beta) is normally secreted in a latent form, and plasmin-mediated proteolytic cleavage of latency-associated peptide (LAP), a component of latent TGF-beta complex that makes the complex inactive, activates latent TGF-beta. In the present study, we investigated the possible involvement of calpain, one of the cysteine proteases, in the activation of latent TGF-beta. When...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Calpain Protease Function and Regulation
• Share to Signaling Pathways in Disease