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Article

Helicobacter pylori phase variation, immune modulation and gastric autoimmunity.

Nature reviews. Microbiology - 1 Feb 2006

Bergman Mathijs, Del Prete Gianfranco, van Kooyk Yvette, Appelmelk Ben

Abstract excerpt

Helicobacter pylori can be regarded as a model pathogen for studying persistent colonization of humans. Phase-variable expression of Lewis blood-group antigens by H. pylori allows this microorganism to modulate the host T-helper-1-cell versus T-helper-2-cell response. We describe a model in which interactions between host lectins and pathogen carbohydrates facilitate asymptomatic persistence of H. pylori. This...

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PMID: 16415930
DOI: 10.1038/nrmicro1344

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Helicobacter pylori phase variation, immune modulation and gastric autoimmunity.PMID 16415930Read ↗

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