Article
An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population.
Psychiatry and clinical neurosciences - 1 Oct 1997
Ishiguro H, Arinami T, Yamada K, Otsuka Y, Toru M, Shibuya H
Abstract excerpt
A polymorphism in the 5' region of the serotonin transporter gene modulates its transcription efficiency. Its short allele has been reported to be associated with neurotic traits. The serotonin transporter is the action site of selective serotonin re-uptake inhibitors, widely used in the treatmen...
Topics
- Adult
- Aged
- Alleles
- Carrier Proteins
- DNA
- Double-Blind Method
- Female
- Genotype
- Humans
- Japan
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins
- Middle Aged
- Nerve Tissue Proteins
- Panic Disorder
- Polymorphism, Genetic
- Serotonin