Article
Characterization of the ligand-binding site of the transferrin receptor in Trypanosoma brucei demonstrates a structural relationship with the N-terminal domain of the variant surface glycoprotein.
The EMBO journal - 15 Dec 1997
Salmon D, Hanocq-Quertier J, Paturiaux-Hanocq F, Pays A, Tebabi P, Nolan D P, Michel A, Pays E
Abstract excerpt
The Trypanosoma brucei transferrin (Tf) receptor is a heterodimer encoded by ESAG7 and ESAG6, two genes contained in the different polycistronic transcription units of the variant surface glycoprotein (VSG) gene. The sequence of ESAG7/6 differs slightly between different units, so that receptors...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cattle
- Dimerization
- Female
- Genes, Protozoan
- Genetic Variation
- Ligands
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Oocytes
- Protein Structure, Secondary