Article
Mutations at the lipoprotein lipase gene locus in subjects with diabetes mellitus, obesity and lipaemia.
Clinical science (London, England : 1979) - 1 Oct 1997
Zhang Q, Cavallero E, Hoffmann M M, Cavanna J, Kay A, Charles A, Braschi S, Marz W, Perlemuter L, Jacotot B, Galton D J
Abstract excerpt
1. The common association of obesity, diabetes mellitus and hyperlipidaemia may have a primary aetiological basis. Insulin resistance has been postulated as a possible cause, but defects in the plasma transport of triacylglycerol or fatty acids could also be primary determinants. 2. We have therefore studied 18 patients with diabetes mellitus, obesity and severe hypertriglyceridaemia for defects of a key protein...
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