Article
Cell signaling pathways elicited by asbestos.
Environmental health perspectives - 1 Sept 1997
Mossman B T, Faux S, Janssen Y, Jimenez L A, Timblin C, Zanella C, Goldberg J, Walsh E, Barchowsky A, Driscoll K
Abstract excerpt
In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene transactivation. These cascades may be initiated at the cell surface after interaction of minerals with the plasma membrane either through receptorlike mechanisms or integrins. Alternatively, signaling pathways may be stimulated by active oxygen species generated both...
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